講座主題：線粒體內膜的CALHM2孔道：細胞代謝調控新機制
專家姓名：王世強
工作單位：北京大學
講座時間：2024年10月18日13:30-14:30
講座地點：八角灣校區行政樓報告廳
主辦單位：煙臺大學生命科學學院
內容摘要：
The calcium homeostasis modulator (CALHM)-2 is a member of the CALHM gene family residing at 10q24.33 of human genome, but its function is yet unknown. We found that CALHM2 forms a mega channel in the inner membrane of mitochondria. CALHM2 channels are opened by ATP and closed by Ca2+. Opened CALHM2 channels are permeable to molecules like ATP and induce fluctuations of mitochondrial membrane potential. CALHM2 knockdown/knockout decreases cytosolic ATP concentration, and thereby compromises energy-sensitive processes, such as intracellular Ca2+ handling. However, CALHM2 loss-of-function elevates ATP concentration in the mitochondrial matrix, dephosphorylates key enzymes in the mammalian target of rapamycin (mTOR) pathway, and promotes longevity in CALHM2 knockout mice. These findings reveal that CALHM2 constitutes a novel regulator of mitochondrial metabolism, which may has important implications in aging and diseases.
主講人介紹：
王世強，北京大學生命科學學院長江學者特聘教授，國家杰出青年科學基金獲得者，國家“萬人計劃”領軍人才。長期從事細胞鈣信號轉導研究，從分子間相互作用的角度闡明心肌細胞興奮收縮耦聯的分子機制，系統研究了心肌肥厚、心力衰竭、心律失常的心臟疾病條件下興奮收縮耦聯的結構和功能重塑，闡明其中鈣信號、microRNA、相關蛋白及其啟動子和轉錄因子的病理變化規律，提出治療或逆轉這些病理過程的新理論。先后承擔“973”計劃、“863”計劃、國家重點研發計劃，以及國家自然科學基金重點項目、重大研究計劃等科研項目，系列重要成果發表于Nature、Circulation Research、PNAS等期刊，曾獲北京市優秀教師、全國優秀科技工作者、國家級一流本科課程、教育部自然科學一等獎、國家自然科學二等獎、國務院政府特殊津貼等榮譽。
